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5.3.6 Dopamine Recent studies have demonstrated that certain gut microbes can synthesize dopamine or its precursors through specific metabolic pathways, thereby indirectly regulating host physiological functions, and dopamine can stabilize GPX4 and mitigate ferroptosis-related oxidative stress (171)

Co-administration of isoniazid with acetaminophen was reported to increase acetaminophen oxidation, promote GSH depletion and NAPQI formation and ultimately lead to increased hepatotoxicity [65,66,76]

Excess alcohol consumption has a directly toxic effect on the gut epithelium, leading to loss of mucosal integrity and leakage of microbial products into the circulation

Vitamin D, vitamin D receptor and tissue barriers